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Recent clinical studies reported that SGLT-2is improved hypertension and atrial fibrillation by modulating the overstimulated renin-angiotensin-aldosterone system (RAAS) and suppressing the sympathetic nervous system (SNS) by directly/indirectly acting on the rostral ventrolateral medulla

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47CanaleseJ, GoveCD, GimsonAE, WilkinsonSP, WardleEN, WilliamsR